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KMID : 0855520140270030131
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Korean Journal of Physical Anthropology
2014 Volume.27 No. 3 p.131 ~ p.136
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Association between Mitochondrial D-loop Polymorphism and Copy Number
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Lee Jae-Ho
Kim Dae-Kwang
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Abstract
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Mitochondria in cancer have genetic instability like genetic mutations or polymorphisms, and D-loop is hot spot region and is suggested its association with cancer prognosis. Genetic variations of D-loop were associated with mitochondrial copy number. In present study, mitochondrial polymorphism in D-loop (D310 and D514) was studied in 108 DNAs from health individuals and its association with mitochondrial copy number was also investigated. In D310 polymorphism, C7 was most common (37.7%, 40/108), and C8 and C9 was found in 32.1% and 30.2%, respectively. In D514 polymorphism, (CA)5 and (CA)4 was shown in 61.4% and 38.6%, respectively. Mitochondrial copy number was increased in 40.7% while it was decreased in 59.3%. There was no association between mitochondrial polymorphism and copy number. Follow-up study should be needed to confirm its change in same individuals.
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KEYWORD
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Mitochondrial polymorphism, Mitochondrial copy number, D-loop
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